#6246 PIVKA II IS A BIOMARKER FOR PREDICTING CORONARY CALCIFICATION IN HEMODIALYSIS PATIENTS WITH DIABETES

Abstract Background and Aims Vascular calcification (VC) is a commonly occurring serious complication in end-stage renal disease (ESRD) patients that increases mortality. Vitamin K deficiency well known to cause the occurrence of VC through inactivation dependent proteins (VKDP). Therefore, marker can easily predict risk due vitamin needed clinical practice. In this study, we aim investigate whether measurable absence II (PIVKA-II) serve as surrogate for predicting coronary artery (CAC) ESRD receiving hemodialysis what factors influence prediction CAC. Method This study an observational conducted on treatment. Patients with liver cirrhosis, HCC, or history stent placement were excluded, active infectious diseases. CAC score was measured by Non-enhanced computed tomography, before starting hemodialysis, blood samples collected measure PIVKA-II, osteocalcin (OC), bone-specific alkaline phosphatase (BAP) among other bone markers. PIVKA-II two times 3 months interval, average value calculated. Additionally, ankle-brachial index (ABI) DEXA densitometry also performed. Results 69 dialysis participated. Among them, 34 had diabetes mellitus (DM). The compared groups based presence DM. results showed DM higher Body Mass Index (BMI) (p = 0.01) frequency vascular diseases such cerebrovascular 0.004). group LDL cholesterol levels 0.03), but there no significant difference between terms BAP, Osteocalcin (Table 1). When analyzing correlation all patients, (r -0.37, p 0.002) CRP 0.28, 0.03) found have correlation, 0.065, Figure 1A), BAP 0.57), OC 0.45) did not. group, statistically 0.283, 0.001), (Figure 1B) CaxP, cholesterol, CRP, 0.7, 0.4, 0.3, 0.7 0.4 respectively). Conclusion suggest who undergo dialysis, be clinically useful associated deficiency. because diabetic may more pronounced VKDP deficiency, additional research fully understand relationship.